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DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is central to the regulation of the DNA damage response and repair through nonhomologous end joining. The structure has proved challenging due to its large size and multiple HEAT repeats. We have recently reported crystals of selenomethionine...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Methods Enzymol
Main Authors: Chirgadze, Dimitri Y., Ascher, David B., Blundell, Tom L., Sibanda, Bancinyane L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495172/
https://ncbi.nlm.nih.gov/pubmed/28668119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2017.04.001
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