Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment

Radiotherapy is based on the induction of lethal DNA damage, primarily DNA double-strand breaks (DSB). Efficient DSB repair via Non-Homologous End Joining or Homologous Recombination can therefore undermine the efficacy of radiotherapy. By suppressing DNA-DSB repair with hyperthermia (HT) and DNA-PK...

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Vydáno v:Oncotarget
Hlavní autoři: van Oorschot, Bregje, Granata, Giovanna, Di Franco, Simone, Cate, Rosemarie ten, Rodermond, Hans M., Todaro, Matilde, Medema, Jan Paul, Franken, Nicolaas A.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323171/
https://ncbi.nlm.nih.gov/pubmed/27602767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11798
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