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Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor
A key question regarding the signaling mechanism for G protein-coupled receptors (GPCRs) is what triggers agonism versus antagonism. Peptide analogs derived from the chemokine, complement fragment 5 anaphylatoxin (C5a), can act as agonists or antagonists to the C5a receptor, a member of the GPCR fam...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC549436/ https://ncbi.nlm.nih.gov/pubmed/15710877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500016102 |
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