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Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor

A key question regarding the signaling mechanism for G protein-coupled receptors (GPCRs) is what triggers agonism versus antagonism. Peptide analogs derived from the chemokine, complement fragment 5 anaphylatoxin (C5a), can act as agonists or antagonists to the C5a receptor, a member of the GPCR fam...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Buck, Elizabeth, Wells, James A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2005
Ämnen:
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549436/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15710877/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0500016102
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