Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist

Naturally occurring mutations of G protein-coupled receptors (GPCRs) causing misfolding and failure to traffic to the cell surface can result in disease states. Some small-molecule orthosteric ligands can rescue such misfolded receptors, presumably by facilitating their correct folding and shuttling...

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Detalhes bibliográficos
Main Authors: Newton, Claire L., Whay, Adele M., McArdle, Craig A., Zhang, Meilin, van Koppen, Chris J., van de Lagemaat, Ruud, Segaloff, Deborah L., Millar, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084114/
https://ncbi.nlm.nih.gov/pubmed/21482767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015723108
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