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Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein–Coupled Receptor Antagonist

Adhesion G protein–coupled receptors (aGPCRs) have emerging roles in development and tissue maintenance and is the most prevalent GPCR subclass mutated in human cancers, but to date, no drugs have been developed to target them in any disease. aGPCR extracellular domains contain a conserved subdomain...

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Publicado en:Mol Pharmacol
Autores principales: Stoveken, Hannah M., Bahr, Laura L., Anders, M. W., Wojtovich, Andrew P., Smrcka, Alan V., Tall, Gregory G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998661/
https://ncbi.nlm.nih.gov/pubmed/27338081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.104828
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