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In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication

We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes sim...

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書誌詳細
主要な著者: Kern, Earl R., Kushner, Nicole L., Hartline, Caroll B., Williams-Aziz, Stephanie L., Harden, Emma A., Zhou, Shaoman, Zemlicka, Jiri, Prichard, Mark N.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC549243/
https://ncbi.nlm.nih.gov/pubmed/15728900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1039-1045.2005
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