In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication

We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes sim...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Kern, Earl R., Kushner, Nicole L., Hartline, Caroll B., Williams-Aziz, Stephanie L., Harden, Emma A., Zhou, Shaoman, Zemlicka, Jiri, Prichard, Mark N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2005
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549243/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15728900/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.3.1039-1045.2005
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