In Vitro Anti-Human Immunodeficiency Virus Activities of Z- and E-Methylenecyclopropane Nucleoside Analogues and Their Phosphoro-l-Alaninate Diesters

Nucleoside analogues with a Z- or an E-methylenecyclopropane moiety were synthesized and examined for activity against human immunodeficiency virus type 1 (HIV-1) in vitro. The addition of a methyl phenyl phosphoro-l-alaninate moiety to modestly active analogues resulted in potentiation of their ant...

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Autores principales: Uchida, Hiroyuki, Kodama, Eiichi N., Yoshimura, Kazuhisa, Maeda, Yosuke, Kosalaraksa, Pope, Maroun, Victor, Qiu, Yao-Ling, Zemlicka, Jiri, Mitsuya, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1999
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC89303/
https://ncbi.nlm.nih.gov/pubmed/10348777
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