In Vitro Anti-Human Immunodeficiency Virus Activities of Z- and E-Methylenecyclopropane Nucleoside Analogues and Their Phosphoro-l-Alaninate Diesters

Nucleoside analogues with a Z- or an E-methylenecyclopropane moiety were synthesized and examined for activity against human immunodeficiency virus type 1 (HIV-1) in vitro. The addition of a methyl phenyl phosphoro-l-alaninate moiety to modestly active analogues resulted in potentiation of their ant...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Uchida, Hiroyuki, Kodama, Eiichi N., Yoshimura, Kazuhisa, Maeda, Yosuke, Kosalaraksa, Pope, Maroun, Victor, Qiu, Yao-Ling, Zemlicka, Jiri, Mitsuya, Hiroaki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89303/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10348777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.6.1487
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