In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication

We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes sim...

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Bibliographische Detailangaben
Hauptverfasser: Kern, Earl R., Kushner, Nicole L., Hartline, Caroll B., Williams-Aziz, Stephanie L., Harden, Emma A., Zhou, Shaoman, Zemlicka, Jiri, Prichard, Mark N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC549243/
https://ncbi.nlm.nih.gov/pubmed/15728900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1039-1045.2005
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