Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus Infections

We reported previously that purine 2-(hydroxymethyl)methylenecyclopropane analogs have good activity against cytomegalovirus infection. A second-generation analog, (Z)-9-{[2,2-bis-(hydroxymethyl)cyclopropylidene]methyl}guanine (ZSM-I-62, cyclopropavir [CPV]), has particularly good activity against m...

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Main Authors: Kern, Earl R., Bidanset, Deborah J., Hartline, Caroll B., Yan, Zhaohua, Zemlicka, Jiri, Quenelle, Debra C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC529216/
https://ncbi.nlm.nih.gov/pubmed/15561852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4745-4753.2004
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