Inhibition of Herpesvirus Replication by 5-Substituted 4′-Thiopyrimidine Nucleosides

A series of 4′-thionucleosides were synthesized and evaluated for activities against orthopoxviruses and herpesviruses. We reported previously that one analog, 5-iodo-4′-thio-2′-deoxyuridine (4′-thioIDU), exhibits good activity both in vitro and in vivo against two orthopoxviruses. This compound als...

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Detalhes bibliográficos
Main Authors: Prichard, Mark N., Quenelle, Debra C., Hartline, Caroll B., Harden, Emma A., Jefferson, Geraldine, Frederick, Samuel L., Daily, Shannon L., Whitley, Richard J., Tiwari, Kamal N., Maddry, Joseph A., Secrist, John A., Kern, Earl R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786333/
https://ncbi.nlm.nih.gov/pubmed/19770274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00417-09
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