Inhibition of Herpesvirus Replication by 5-Substituted 4′-Thiopyrimidine Nucleosides

A series of 4′-thionucleosides were synthesized and evaluated for activities against orthopoxviruses and herpesviruses. We reported previously that one analog, 5-iodo-4′-thio-2′-deoxyuridine (4′-thioIDU), exhibits good activity both in vitro and in vivo against two orthopoxviruses. This compound als...

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Bibliografische gegevens
Hoofdauteurs: Prichard, Mark N., Quenelle, Debra C., Hartline, Caroll B., Harden, Emma A., Jefferson, Geraldine, Frederick, Samuel L., Daily, Shannon L., Whitley, Richard J., Tiwari, Kamal N., Maddry, Joseph A., Secrist, John A., Kern, Earl R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2009
Onderwerpen:
Antiviral Agents
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786333/
https://ncbi.nlm.nih.gov/pubmed/19770274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00417-09
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