Inhibition of Herpesvirus Replication by 5-Substituted 4′-Thiopyrimidine Nucleosides

A series of 4′-thionucleosides were synthesized and evaluated for activities against orthopoxviruses and herpesviruses. We reported previously that one analog, 5-iodo-4′-thio-2′-deoxyuridine (4′-thioIDU), exhibits good activity both in vitro and in vivo against two orthopoxviruses. This compound als...

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Hauptverfasser: Prichard, Mark N., Quenelle, Debra C., Hartline, Caroll B., Harden, Emma A., Jefferson, Geraldine, Frederick, Samuel L., Daily, Shannon L., Whitley, Richard J., Tiwari, Kamal N., Maddry, Joseph A., Secrist, John A., Kern, Earl R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786333/
https://ncbi.nlm.nih.gov/pubmed/19770274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00417-09
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