DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

End resection of DNA double-strand breaks (DSBs) to generate 3′-single-stranded DNA facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair by the error-prone non-homologous end joining (NHEJ) pathway. Activation of DNA end resection involves phosphorylation of the...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Tomimatsu, Nozomi, Mukherjee, Bipasha, Harris, Janelle Louise, Boffo, Francesca Ludovica, Hardebeck, Molly Catherine, Potts, Patrick Ryan, Khanna, Kum Kum, Burma, Sandeep
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
DNA and Chromosomes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491765/
https://ncbi.nlm.nih.gov/pubmed/28515316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772475
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares