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DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair
End resection of DNA double-strand breaks (DSBs) to generate 3′-single-stranded DNA facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair by the error-prone non-homologous end joining (NHEJ) pathway. Activation of DNA end resection involves phosphorylation of the...
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| Foilsithe in: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society for Biochemistry and Molecular Biology
2017
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5491765/ https://ncbi.nlm.nih.gov/pubmed/28515316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772475 |
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