DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

End resection of DNA double-strand breaks (DSBs) to generate 3′-single-stranded DNA facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair by the error-prone non-homologous end joining (NHEJ) pathway. Activation of DNA end resection involves phosphorylation of the...

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Udgivet i:J Biol Chem
Main Authors: Tomimatsu, Nozomi, Mukherjee, Bipasha, Harris, Janelle Louise, Boffo, Francesca Ludovica, Hardebeck, Molly Catherine, Potts, Patrick Ryan, Khanna, Kum Kum, Burma, Sandeep
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491765/
https://ncbi.nlm.nih.gov/pubmed/28515316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772475
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