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Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions
The resection of DNA double-strand breaks (DSBs) to generate ssDNA tails is a pivotal event in the cellular response to these breaks. In the two-step model of resection, primarily elucidated in yeast, initial resection by Mre11/CtIP is followed by extensive resection by two distinct pathways involvi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319278/ https://ncbi.nlm.nih.gov/pubmed/22326273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.01.006 |
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