Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization

PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signalling. Due to its critical role in suppressing the potent signalling pathway, it is one of the most mutated tumour suppressors, especially in brain tumours. It is generally thought that PTEN deficiencies predominantly result from...

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Bibliographische Detailangaben
Veröffentlicht in:Oncogene
Hauptverfasser: Yang, Jr-M, Schiapparelli, P, Nguyen, H-N, Igarashi, A, Zhang, Q, Abbadi, S, Amzel, L M, Sesaki, H, Quiñones-Hinojosa, A, Iijima, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491373/
https://ncbi.nlm.nih.gov/pubmed/28263967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.493
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