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Engineering PTEN function: Membrane association and activity
Many tumors are associated with deficiency of the tumor suppressor, PTEN, a PIP3 phosphatase that turns off PIP3 signaling. The major site of PTEN action is the plasma membrane, where PIP3 is produced by PI3 kinases. However, the mechanism and functional importance of PTEN membrane recruitment are p...
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| 出版年: | Methods |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4388803/ https://ncbi.nlm.nih.gov/pubmed/25448479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2014.10.018 |
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