Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN

Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second messenger PIP3, which drives cell proliferation and migration. In the nucleus, PTEN controls DNA repair and genome stability...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Nguyen, Hoai-Nghia, Yang, Jr-Ming, Miyamoto, Takafumi, Itoh, Kie, Rho, Elmer, Zhang, Qiang, Inoue, Takanari, Devreotes, Peter N., Sesaki, Hiromi, Iijima, Miho
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517176/
https://ncbi.nlm.nih.gov/pubmed/26216063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12600
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