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Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN

Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second messenger PIP3, which drives cell proliferation and migration. In the nucleus, PTEN controls DNA repair and genome stability...

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Publicado en:Sci Rep
Autores principales: Nguyen, Hoai-Nghia, Yang, Jr-Ming, Miyamoto, Takafumi, Itoh, Kie, Rho, Elmer, Zhang, Qiang, Inoue, Takanari, Devreotes, Peter N., Sesaki, Hiromi, Iijima, Miho
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517176/
https://ncbi.nlm.nih.gov/pubmed/26216063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12600
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