Mechanism of Human PTEN Localization Revealed by Heterologous Expression in Dictyostelium

Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated tumor suppressor genes in cancers. PTEN plays a central role in phosphatidylinositol (3,4,5)-trisphosphate (PIP3) signaling and converts PIP3 to phosphatidylinositol (4,5)-bisphosphate (PIP2) at the plasma membrane. Despite...

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Main Authors: Nguyen, Hoai-Nghia, Afkari, Yashar, Senoo, Hiroshi, Sesaki, Hiromi, Devreotes, Peter N., Iijima, Miho
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041858/
https://ncbi.nlm.nih.gov/pubmed/24292679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.507
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