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Mechanism of Human PTEN Localization Revealed by Heterologous Expression in Dictyostelium
Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated tumor suppressor genes in cancers. PTEN plays a central role in phosphatidylinositol (3,4,5)-trisphosphate (PIP3) signaling and converts PIP3 to phosphatidylinositol (4,5)-bisphosphate (PIP2) at the plasma membrane. Despite...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041858/ https://ncbi.nlm.nih.gov/pubmed/24292679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.507 |
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