The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma

The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in the nucleus maintains genome integrity. Here, using nuclear PT...

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Vydáno v:iScience
Hlavní autoři: Kato, Takashi, Yamada, Tatsuya, Nakamura, Hideki, Igarashi, Atsushi, Anders, Robert A., Sesaki, Hiromi, Iijima, Miho
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516300/
https://ncbi.nlm.nih.gov/pubmed/33083717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101548
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