The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma

The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in the nucleus maintains genome integrity. Here, using nuclear PT...

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Bibliographic Details
Published in:iScience
Main Authors: Kato, Takashi, Yamada, Tatsuya, Nakamura, Hideki, Igarashi, Atsushi, Anders, Robert A., Sesaki, Hiromi, Iijima, Miho
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516300/
https://ncbi.nlm.nih.gov/pubmed/33083717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101548
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