The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma

The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in the nucleus maintains genome integrity. Here, using nuclear PT...

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發表在:iScience
Main Authors: Kato, Takashi, Yamada, Tatsuya, Nakamura, Hideki, Igarashi, Atsushi, Anders, Robert A., Sesaki, Hiromi, Iijima, Miho
格式: Artigo
語言:Inglês
出版: Elsevier 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516300/
https://ncbi.nlm.nih.gov/pubmed/33083717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101548
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