載入...

The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma

The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in the nucleus maintains genome integrity. Here, using nuclear PT...

全面介紹

Na minha lista:
書目詳細資料
發表在:iScience
Main Authors: Kato, Takashi, Yamada, Tatsuya, Nakamura, Hideki, Igarashi, Atsushi, Anders, Robert A., Sesaki, Hiromi, Iijima, Miho
格式: Artigo
語言:Inglês
出版: Elsevier 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516300/
https://ncbi.nlm.nih.gov/pubmed/33083717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101548
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!