Loading...

REDD1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis

OBJECTIVE: REDD1 is an endogenous inhibitor of mTOR that regulates cellular stress responses. REDD1 expression is decreased in aged and osteoarthritis (OA) cartilage and it regulates mTOR signaling and autophagy in articular chondrocytes in vitro. The present study investigated the effects of REDD1...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Arthritis Rheumatol
Main Authors: Alvarez-Garcia, Oscar, Matsuzaki, Tokio, Olmer, Merissa, Plate, Lars, Kelly, Jeffery W., Lotz, Martin K.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489357/
https://ncbi.nlm.nih.gov/pubmed/28334504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40104
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!