Llwytho...

REDD1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis

OBJECTIVE: REDD1 is an endogenous inhibitor of mTOR that regulates cellular stress responses. REDD1 expression is decreased in aged and osteoarthritis (OA) cartilage and it regulates mTOR signaling and autophagy in articular chondrocytes in vitro. The present study investigated the effects of REDD1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arthritis Rheumatol
Prif Awduron: Alvarez-Garcia, Oscar, Matsuzaki, Tokio, Olmer, Merissa, Plate, Lars, Kelly, Jeffery W., Lotz, Martin K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489357/
https://ncbi.nlm.nih.gov/pubmed/28334504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40104
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