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Elongation Affinity, Activation Barrier, and Stability of Aβ42 Oligomers/Fibrils in Physiological Saline

Amyloid-beta (Aβ) peptides, Aβ40 and the more neurotoxic Aβ42, have been the subject of many research efforts for Alzheimer's disease. In two recent independent investigations, the atomistic structure of Aβ42 fibril has been clearly established in the S-shaped conformation consisting of three β...

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Détails bibliographiques
Publié dans:Biochem Biophys Res Commun
Auteurs principaux: Rodriguez, Roberto A, Chen, Liao Y, Plascencia-Villa, Germán, Perry, George
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489073/
https://ncbi.nlm.nih.gov/pubmed/28427941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.04.084
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