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Elongation Affinity, Activation Barrier, and Stability of Aβ42 Oligomers/Fibrils in Physiological Saline

Amyloid-beta (Aβ) peptides, Aβ40 and the more neurotoxic Aβ42, have been the subject of many research efforts for Alzheimer's disease. In two recent independent investigations, the atomistic structure of Aβ42 fibril has been clearly established in the S-shaped conformation consisting of three β...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Biophys Res Commun
Hauptverfasser: Rodriguez, Roberto A, Chen, Liao Y, Plascencia-Villa, Germán, Perry, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5489073/
https://ncbi.nlm.nih.gov/pubmed/28427941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2017.04.084
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