Dapagliflozin suppresses glucagon signaling in rodent models of diabetes

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of antidiabetic drug used for the treatment of diabetes. These drugs are thought to lower blood glucose by blocking reabsorption of glucose by SGLT2 in the proximal convoluted tubules of the kidney. To investigate the effect of inhibiting...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wang, May-yun, Yu, Xinxin, Lee, Young, McCorkle, Sara Kay, Chen, Shiuhwei, Li, Jianping, Wang, Zhao V., Davidson, Jaime A., Scherer, Philipp E., Holland, William L., Unger, Roger H., Roth, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488956/
https://ncbi.nlm.nih.gov/pubmed/28584109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705845114
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