Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

Insulin monotherapy can neither maintain normoglycemia in type 1 diabetes (T1D) nor prevent the long-term damage indicated by elevated glycation products in blood, such as glycated hemoglobin (HbA1c). Here we find that hyperglycemia, when unaccompanied by an acute increase in insulin, enhances itsel...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wang, May-Yun, Yan, Hai, Shi, Zhiqing, Evans, Matthew R., Yu, Xinxin, Lee, Young, Chen, Shiuhwei, Williams, Annie, Philippe, Jacques, Roth, Michael G., Unger, Roger H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345619/
https://ncbi.nlm.nih.gov/pubmed/25675519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424934112
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