Metabolic manifestations of insulin deficiency do not occur without glucagon action

To determine unambiguously if suppression of glucagon action will eliminate manifestations of diabetes, we expressed glucagon receptors in livers of glucagon receptor-null (GcgR(−/−)) mice before and after β-cell destruction by high-dose streptozotocin. Wild type (WT) mice developed fatal diabetic k...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lee, Young, Berglund, Eric D., Wang, May-yun, Fu, Xiaorong, Yu, Xinxin, Charron, Maureen J., Burgess, Shawn C., Unger, Roger H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443167/
https://ncbi.nlm.nih.gov/pubmed/22891336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205983109
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