Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

OBJECTIVE: To determine the role of glucagon action in the metabolic phenotype of untreated insulin deficiency. RESEARCH DESIGN AND METHODS: We compared pertinent clinical and metabolic parameters in glucagon receptor-null (Gcgr(−/−)) mice and wild-type (Gcgr(+/+)) controls after equivalent destruct...

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Bibliographic Details
Main Authors: Lee, Young, Wang, May-Yun, Du, Xiu Quan, Charron, Maureen J., Unger, Roger H.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2011
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028337/
https://ncbi.nlm.nih.gov/pubmed/21270251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0426
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