Leptin therapy in insulin-deficient type I diabetes

In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined with low-dose insulin reverses the catabolic state through suppression of hyperglucagonemia. Additionally, it mimics the anabolic actions of insulin monotherapy and normalizes hemoglobin A1c with far less g...

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Main Authors: Wang, May-yun, Chen, Lijun, Clark, Gregory O., Lee, Young, Stevens, Robert D., Ilkayeva, Olga R., Wenner, Brett R., Bain, James R., Charron, Maureen J., Newgard, Christopher B., Unger, Roger H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Feature Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841945/
https://ncbi.nlm.nih.gov/pubmed/20194735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909422107
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