Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

The high-K(m) glucose transporter, GLUT-2, and the high-K(m) hexokinase of β cells, glucokinase (GK), are required for glucose-stimulated insulin secretion (GSIS). GLUT-2 expression in β cells of Zucker diabetic fatty (ZDF) rats is profoundly reduced at the onset of β-cell dysfunction of diabetes. B...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, May-Yun, Koyama, Kazunori, Shimabukuro, Michio, Mangelsdorf, David, Newgard, Christopher B., Unger, Roger H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21741/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751766/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11921
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