Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets

We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor (Ab-4) to maintain glucose homeostasis in type 1 diabetic rodents. We noted durable and sustained improvements in glycemia which persist long after treatment withdrawal. Ab-4 promoted β-cell survival and enhance...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Wang, May-Yun, Dean, E. Danielle, Quittner-Strom, Ezekiel, Zhu, Yi, Chowdhury, Kamrul H., Zhang, Zhuzhen, Zhao, Shangang, Li, Na, Ye, Reshing, Lee, Young, Zhang, Yiyi, Chen, Shiuhwei, Yu, Xinxin, Leonard, Derek C., Poffenberger, Greg, Von Deylen, Alison, McCorkle, S. Kay, Schlegel, Amnon, Sloop, Kyle W., Efanov, Alexander M., Gimeno, Ruth E., Scherer, Philipp E., Powers, Alvin C., Unger, Roger H., Holland, William L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936318/
https://ncbi.nlm.nih.gov/pubmed/33619103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022142118
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