A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

SUMMARY: The common genetic variation at rs8004664 in the FOXN3 gene is independently and significantly associated with fasting blood glucose, but not insulin, in non-diabetic humans. Recently, we reported that primary hepatocytes from rs8004664 hyperglycemia risk allele carriers have increased FOXN...

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I publikationen:Cell Rep
Huvudupphovsmän: Karanth, Santhosh, Adams, J.D., Serrano, Maria de los Angeles, Quittner-Strom, Ezekiel B., Simcox, Judith, Villanueva, Claudio J., Ozcan, Lale, Holland, William L., Yost, H. Joseph, Vella, Adrian, Schlegel, Amnon
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086569/
https://ncbi.nlm.nih.gov/pubmed/29996093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.039
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