Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

The antidiabetic potential of glucagon receptor antagonism presents an opportunity for use in an insulin-centric clinical environment. To investigate the metabolic effects of glucagon receptor antagonism in type 2 diabetes, we treated Lepr(db/db) and Lep(ob/ob) mice with REMD 2.59, a human monoclona...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Sharma, Ankit X., Quittner-Strom, Ezekiel B., Lee, Young, Johnson, Joshua A., Martin, Sarah A., Yu, Xinxin, Li, Jianping, Lu, John, Cai, Zheqing, Chen, Shiuhwei, Wang, May-yun, Zhang, Yiyi, Pearson, Mackenzie J., Dorn, Andie C., McDonald, Jeffrey G., Gordillo, Ruth, Yan, Hai, Thai, Dung, Wang, Zhao V., Unger, Roger H., Holland, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5978750/
https://ncbi.nlm.nih.gov/pubmed/29444429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.065
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