Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure

Mice were treated with a fully human monoclonal glucagon receptor antagonistic antibody REMD2.59 following myocardial infarction or pressure overload. REMD2.59 treatment blunted cardiac hypertrophy and fibrotic remodeling, and attenuated contractile dysfunction at 4 weeks after myocardial infarction...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JACC Basic Transl Sci
Egile Nagusiak: Gao, Chen, Ren, Shuxun Vincent, Yu, Junyi, Baal, Ulysis, Thai, Dung, Lu, John, Zeng, Chunyu, Yan, Hai, Wang, Yibin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2019
Gaiak:
PRECLINICAL RESEARCH
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488764/
https://ncbi.nlm.nih.gov/pubmed/31061918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.11.001
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