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The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload–induced heart failure
Heart failure is associated with induction of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). The serine/threonine protein kinase/endoribonuclease IRE1α is a key protein in ER stress signal transduction. IRE1α activity can induce both protective UPR and apoptotic downstrea...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6016466/ https://ncbi.nlm.nih.gov/pubmed/29769316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003448 |
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