Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase

Heavy-enzyme isotope effects ((15)N-, (13)C-, and (2)H-labeled protein) explore mass-dependent vibrational modes linked to catalysis. Transition path-sampling (TPS) calculations have predicted femtosecond dynamic coupling at the catalytic site of human purine nucleoside phosphorylase (PNP). Coupling...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Harijan, Rajesh K., Zoi, Ioanna, Antoniou, Dimitri, Schwartz, Steven D., Schramm, Vern L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488955/
https://ncbi.nlm.nih.gov/pubmed/28584087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704786114
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