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Remote Mutations and Active Site Dynamics Correlate with Catalytic Properties of Purine Nucleoside Phosphorylase
It has been found that with mutation of two surface residues (Lys(22) → Glu and His(104) → Arg) in human purine nucleoside phosphorylase (hPNP), there is an enhancement of catalytic activity in the chemical step. This is true although the mutations are quite remote from the active site, and there ar...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2367194/ https://ncbi.nlm.nih.gov/pubmed/18234834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.121913 |
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