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Remote Mutations and Active Site Dynamics Correlate with Catalytic Properties of Purine Nucleoside Phosphorylase

It has been found that with mutation of two surface residues (Lys(22) → Glu and His(104) → Arg) in human purine nucleoside phosphorylase (hPNP), there is an enhancement of catalytic activity in the chemical step. This is true although the mutations are quite remote from the active site, and there ar...

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書誌詳細
主要な著者: Saen-Oon, Suwipa, Ghanem, Mahmoud, Schramm, Vern L., Schwartz, Steven D.
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367194/
https://ncbi.nlm.nih.gov/pubmed/18234834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.121913
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