Distinct Roles for Conformational Dynamics in Protein-ligand Interactions

Conformational dynamics has an established role in enzyme catalysis, but its contribution to ligand binding and specificity is largely unexplored. Here we used the Tiam1 PDZ domain and an engineered variant (QM PDZ) with broadened specificity to investigate the role of structure and conformational d...

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Publicat a:Structure
Autors principals: Liu, Xu, Speckhard, David C., Shepherd, Tyson R., Sun, Young Joo, Hengel, Sarah R., Yu, Liping, Fowler, C. Andrew, Gakhar, Lokesh, Fuentes, Ernesto J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488749/
https://ncbi.nlm.nih.gov/pubmed/27998539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.019
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