Distinct Roles for Conformational Dynamics in Protein-ligand Interactions

Conformational dynamics has an established role in enzyme catalysis, but its contribution to ligand binding and specificity is largely unexplored. Here we used the Tiam1 PDZ domain and an engineered variant (QM PDZ) with broadened specificity to investigate the role of structure and conformational d...

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發表在:Structure
Main Authors: Liu, Xu, Speckhard, David C., Shepherd, Tyson R., Sun, Young Joo, Hengel, Sarah R., Yu, Liping, Fowler, C. Andrew, Gakhar, Lokesh, Fuentes, Ernesto J.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488749/
https://ncbi.nlm.nih.gov/pubmed/27998539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.019
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