Distinct Roles for Conformational Dynamics in Protein-ligand Interactions

Conformational dynamics has an established role in enzyme catalysis, but its contribution to ligand binding and specificity is largely unexplored. Here we used the Tiam1 PDZ domain and an engineered variant (QM PDZ) with broadened specificity to investigate the role of structure and conformational d...

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Bibliografiske detaljer
Udgivet i:Structure
Main Authors: Liu, Xu, Speckhard, David C., Shepherd, Tyson R., Sun, Young Joo, Hengel, Sarah R., Yu, Liping, Fowler, C. Andrew, Gakhar, Lokesh, Fuentes, Ernesto J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488749/
https://ncbi.nlm.nih.gov/pubmed/27998539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.019
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