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Distinct Roles for Conformational Dynamics in Protein-ligand Interactions
Conformational dynamics has an established role in enzyme catalysis, but its contribution to ligand binding and specificity is largely unexplored. Here we used the Tiam1 PDZ domain and an engineered variant (QM PDZ) with broadened specificity to investigate the role of structure and conformational d...
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| 出版年: | Structure |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5488749/ https://ncbi.nlm.nih.gov/pubmed/27998539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.08.019 |
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