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The Structure of the Tiam1 PDZ Domain/Phospho-Syndecan1 Complex Reveals a Ligand Conformation that Modulates Protein Dynamics

PDZ (PSD-95/Dlg/ZO-1) domains are protein-protein interaction modules often regulated by ligand phosphorylation. Here, we investigated the specificity, structure, and dynamics of Tiam1 PDZ domain/ligand interactions. We show that the PDZ domain specifically binds syndecan1 (SDC1), phosphorylated SDC...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Xu, Shepherd, Tyson R., Murray, Ann M., Xu, Zhen, Fuentes, Ernesto J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086710/
https://ncbi.nlm.nih.gov/pubmed/23395182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.01.004
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