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The Structure of the Tiam1 PDZ Domain/Phospho-Syndecan1 Complex Reveals a Ligand Conformation that Modulates Protein Dynamics
PDZ (PSD-95/Dlg/ZO-1) domains are protein-protein interaction modules often regulated by ligand phosphorylation. Here, we investigated the specificity, structure, and dynamics of Tiam1 PDZ domain/ligand interactions. We show that the PDZ domain specifically binds syndecan1 (SDC1), phosphorylated SDC...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086710/ https://ncbi.nlm.nih.gov/pubmed/23395182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.01.004 |
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