The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner

The small GTPases of the Rho family comprising RhoA, Rac1 and Cdc42 function as molecular switches controlling several essential biochemical pathways in eukaryotic cells. Their activity is cycling between an active GTP-bound and an inactive GDP-bound conformation. The exchange of GDP to GTP is catal...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Keller-Pinter, Aniko, Ughy, Bettina, Domoki, Monika, Pettko-Szandtner, Aladar, Letoha, Tamas, Tovari, Jozsef, Timar, Jozsef, Szilak, Laszlo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679609/
https://ncbi.nlm.nih.gov/pubmed/29121646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187094
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki