The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner

The small GTPases of the Rho family comprising RhoA, Rac1 and Cdc42 function as molecular switches controlling several essential biochemical pathways in eukaryotic cells. Their activity is cycling between an active GTP-bound and an inactive GDP-bound conformation. The exchange of GDP to GTP is catal...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Keller-Pinter, Aniko, Ughy, Bettina, Domoki, Monika, Pettko-Szandtner, Aladar, Letoha, Tamas, Tovari, Jozsef, Timar, Jozsef, Szilak, Laszlo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679609/
https://ncbi.nlm.nih.gov/pubmed/29121646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187094
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