The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner

The small GTPases of the Rho family comprising RhoA, Rac1 and Cdc42 function as molecular switches controlling several essential biochemical pathways in eukaryotic cells. Their activity is cycling between an active GTP-bound and an inactive GDP-bound conformation. The exchange of GDP to GTP is catal...

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Vydáno v:PLoS One
Hlavní autoři: Keller-Pinter, Aniko, Ughy, Bettina, Domoki, Monika, Pettko-Szandtner, Aladar, Letoha, Tamas, Tovari, Jozsef, Timar, Jozsef, Szilak, Laszlo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679609/
https://ncbi.nlm.nih.gov/pubmed/29121646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187094
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