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Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Amo...
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| Published in: | Cell Mol Life Sci |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer International Publishing
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5487891/ https://ncbi.nlm.nih.gov/pubmed/28271164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2494-0 |
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