Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Amo...

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Bibliographic Details
Published in:Cell Mol Life Sci
Main Authors: Kazi, Julhash U., Chougule, Rohit A., Li, Tianfeng, Su, Xianwei, Moharram, Sausan A., Rupar, Kaja, Marhäll, Alissa, Gazi, Mohiuddin, Sun, Jianmin, Zhao, Hui, Rönnstrand, Lars
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487891/
https://ncbi.nlm.nih.gov/pubmed/28271164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2494-0
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