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Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Amo...
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| 出版年: | Cell Mol Life Sci |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer International Publishing
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5487891/ https://ncbi.nlm.nih.gov/pubmed/28271164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2494-0 |
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