Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Amo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Mol Life Sci
Auteurs principaux: Kazi, Julhash U., Chougule, Rohit A., Li, Tianfeng, Su, Xianwei, Moharram, Sausan A., Rupar, Kaja, Marhäll, Alissa, Gazi, Mohiuddin, Sun, Jianmin, Zhao, Hui, Rönnstrand, Lars
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487891/
https://ncbi.nlm.nih.gov/pubmed/28271164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2494-0
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