ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling

The type III receptor tyrosine kinase FLT3 is one of the most commonly mutated oncogenes in acute myeloid leukemia (AML). Inhibition of mutated FLT3 in combination with chemotherapy has displayed promising results in clinical trials. However, one of the major obstacles in targeting FLT3 is the devel...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Kazi, Julhash U., Rupar, Kaja, Marhäll, Alissa, Moharram, Sausan A., Khanum, Fatima, Shah, Kinjal, Gazi, Mohiuddin, Nagaraj, Sachin Raj M., Sun, Jianmin, Chougule, Rohit A., Rönnstrand, Lars
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355336/
https://ncbi.nlm.nih.gov/pubmed/28086240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14577
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