Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling

Fms-like tyrosine kinase (FLT3) is a frequently mutated oncogene in acute myeloid leukemia (AML). FLT3 inhibitors display promising results in a clinical setting, but patients relapse after short-term treatment due to the development of resistant disease. Therefore, a better understanding of FLT3 do...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Moharram, Sausan A., Chougule, Rohit A., Su, Xianwei, Li, Tianfeng, Sun, Jianmin, Zhao, Hui, Rönnstrand, Lars, Kazi, Julhash U.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295388/
https://ncbi.nlm.nih.gov/pubmed/27458164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10760
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