Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Amo...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Mol Life Sci
Egile Nagusiak: Kazi, Julhash U., Chougule, Rohit A., Li, Tianfeng, Su, Xianwei, Moharram, Sausan A., Rupar, Kaja, Marhäll, Alissa, Gazi, Mohiuddin, Sun, Jianmin, Zhao, Hui, Rönnstrand, Lars
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer International Publishing 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487891/
https://ncbi.nlm.nih.gov/pubmed/28271164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2494-0
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