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Comparative Pharmacodynamics of Telavancin and Vancomycin in the Neutropenic Murine Thigh and Lung Infection Models against Staphylococcus aureus

The pharmacodynamics of telavancin and vancomycin were compared using neutropenic murine thigh and lung infection models. Four Staphylococcus aureus strains were included. The telavancin MIC ranged from 0.06 to 0.25 mg/liter, and the vancomycin MIC ranged from 1 to 4 mg/liter. The plasma pharmacokin...

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Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Lepak, Alexander J., Zhao, Miao, Andes, David R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487664/
https://ncbi.nlm.nih.gov/pubmed/28416551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00281-17
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